Association Between Serum Cholesterol and Noncardiovascular Mortality in Older Age
| Autor: | Jan Heeringa, Rachel S. Newson, Albert Hofman, Henning Tiemeier, Janine F. Felix, Jacqueline C. M. Witteman |
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| Přispěvatelé: | Epidemiology, Child and Adolescent Psychiatry / Psychology |
| Rok vydání: | 2011 |
| Předmět: |
Male
Gerontology medicine.medical_specialty Hypercholesterolemia Population Lower risk chemistry.chemical_compound SDG 3 - Good Health and Well-being Cause of Death Neoplasms Internal medicine medicine Humans Registries education Serum cholesterol Aged Netherlands Proportional Hazards Models Aged 80 and over education.field_of_study Proportional hazards model business.industry Cholesterol Cholesterol HDL Hazard ratio Age Factors Middle Aged Health Surveys Survival Analysis Confidence interval chemistry Cardiovascular Diseases Female Geriatrics and Gerontology business Cohort study |
| Zdroj: | Journal of American Geriatrics Society, 59(10), 1779-1785. Wiley-Blackwell Publishing Ltd |
| ISSN: | 0002-8614 |
| Popis: | OBJECTIVES: To clarify the association between cholesterol and noncardiovascular mortality and to evaluate how this association varies across age groups. DESIGN: Prospective population-based cohort study. SETTING: Rotterdam, the Netherlands. PARTICIPANTS: Adults aged 55 to 99 (N = 5,750). MEASUREMENTS: Participants were evaluated for total cholesterol and subfractions and followed for mortality for a median of 13.9 years. Total cholesterol and its subfractions were evaluated in relation to noncardiovascular mortality. Cox regression analyses were conducted in the total sample and within age-groups (55 64, 65 74, 75 84, >= 85). RESULTS: Age- and sex-adjusted analyses showed that each 1-mmol/L increase in total cholesterol was associated with an approximately 12% lower risk of noncardiovascular mortality (hazard ratio (HR) = 0.88, 95% confidence interval (CI) = 0.84-0.92, P < .001). Age group-specific analyses demonstrated that this association reached significance after the age of 65 and increased in magnitude across each subsequent decade. This was driven largely by non-high-density lipoprotein cholesterol (non-HDL-C) (HR = 0.89, 95% CI 0.85-0.93, P < .001) and was partly attributable to cancer mortality. Conversely, HDL-C was not significantly associated with noncardiovascular mortality (HR = 0.92, 95% CI 0.79-1.07, P = .26). CONCLUSION: Higher total cholesterol was associated with a lower risk of noncardiovascular mortality in older adults. This association varied across the late-life span and was stronger in older age groups. Further research is required to examine the mechanisms underlying this association. J Am Geriatr Soc 59:1779-1785, 2011. |
| Databáze: | OpenAIRE |
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