Serotonin system genes contribute to the susceptibility to obesity in Black adolescents
| Autor: | Colin A. Hodgkinson, Susan W. Groth, Thomas J. Mariani, Ying Meng |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nutrition and Dietetics
TPH2 business.industry Endocrinology Diabetes and Metabolism African–American Physiology Single-nucleotide polymorphism Original Articles Overweight medicine.disease RC31-1245 Obesity Childhood obesity serotonin medicine SNP Original Article Serotonin adolescents medicine.symptom business Internal medicine Body mass index childhood obesity |
| Zdroj: | Obesity Science & Practice Obesity Science & Practice, Vol 7, Iss 4, Pp 441-449 (2021) |
| ISSN: | 2055-2238 |
| Popis: | Objective The importance of the central and peripheral serotonin systems in regulating energy balance and obesity development has been highlighted in animal models. Yet, the role of both serotonin systems has not been systematically assessed in humans. The purpose of this study was to investigate the association of genes within both serotonin systems with obesity outcomes in black adolescents. Methods African–American adolescents (n = 1052) whose mothers participated the Memphis New Mother's Study were assessed. In total, 110 polymorphisms mapped to 10 serotonin genes were examined for their associations with standardized body mass index (BMI‐z) scores and waist circumferences using generalized estimating equation models. Results Over 39% of adolescents were overweight or had obesity. Three single nucleotide polymorphisms (SNPs) within TPH2, HTR3B, and SLC6A4, were significantly associated with BMI‐z scores (p |
| Databáze: | OpenAIRE |
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