Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals
| Autor: | Sibylle G. Schwab, Christian P. Müller, Antonia Eirich, Johannes Kornhuber, Dieter B. Wildenauer, Teresa Biermann, Beben Benyamin, Gary K. Hulse |
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| Přispěvatelé: | Eirich, Antonia, Biermann, Teresa, Müller, Christian P, Kornhuber, Johannes, Benyamin, Beben, Hulse, Gary K, Wildenauer, Dieter B, Schwab, Sibylle G |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Genotype Single-nucleotide polymorphism Quantitative trait locus Biology Polymorphism Single Nucleotide Linkage Disequilibrium Heroin 03 medical and health sciences Young Adult 0302 clinical medicine Gene Frequency substance dependence Risk Factors Genetic variation Genetics medicine Humans genetics Genetic Predisposition to Disease heroin dependence Biological Psychiatry Genetics (clinical) Genetic Association Studies Genetic association Substance dependence Heroin Dependence Haplotype Australia Genetic Variation Heritability medicine.disease Psychiatry and Mental health 030104 developmental biology Haplotypes Case-Control Studies Female heroin Calcium-Calmodulin-Dependent Protein Kinase Type 2 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychiatric genetics. 29(1) |
| ISSN: | 1473-5873 |
| Popis: | OBJECTIVES: Susceptibility to heroin dependence is strongly influenced by genetic factors with heritability estimates as high as 0.7. A number of genes, as well as environmental factors, are likely to contribute to its etiology. Not all individuals who have ever tried heroin at some stage during their lifetime become dependent on heroin. It has been suggested that genetic factors might be more important in the transition stage to heroin dependence rather than in environmental exposures and experimenting with heroin. As the features of substance dependence and memory formation have been found to be strikingly similar, we have focused on a key enzyme involved in long-term potentiation and synaptic plasticity, namely the calcium-dependent/calmodulin-dependent protein kinase IIα (CAMKIIa). We hypothesized, that CamK2A genetic variation may play a role in the transition from occasional to regular heroin use. MATERIALS AND METHODS: Using quantitative trait association analysis, we addressed this hypothesis by correlating the self-reported time interval between occasional and regular heroin use with the frequency of 12 single nucleotide polymorphisms located within the genomic region of the CamK2A gene. A sample of 570 Caucasian patients was available for analysis. RESULTS: Single marker association analysis (rs10066581, P=0.007), as well as haplotype analysis (global P=0.005), suggested an association with the quantitative trait 'time interval from occasional to regular heroin use CONCLUSION: Our results propose that genetic variants located in the genomic region of the CamK2A gene may be involved in transition time from occasional to regular heroin use. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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