Early metabolic effects of sepsis in the preterm infant: Lactic acidosis and increased glucose requirement
| Autor: | W Patrick Zeller, Thomas F. Myers, Michael J. Fitzgerald, Masakatsu Goto |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Time Factors medicine.medical_treatment Physiology Infant Premature Diseases Urine Carbohydrate metabolism Sepsis chemistry.chemical_compound medicine Humans Insulin Lactic Acid Acidosis Analysis of Variance business.industry Infant Newborn Bacterial Infections Metabolism medicine.disease Lactic acid Surgery Glucose chemistry Lactic acidosis Pediatrics Perinatology and Child Health Lactates Acidosis Lactic medicine.symptom business Biomarkers Infant Premature |
| Zdroj: | The Journal of Pediatrics. 121:951-955 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(05)80350-6 |
| Popis: | The effects of sepsis on carbohydrate metabolism were studied in preterm newborn infants (weight1.2 kg, appropriate for gestational age) without maternal endocrine problems who were being examined for infection. Plasma glucose, lactate, and insulin concentrations were measured at initial evaluation and then every 8 hours for a total of 48 hours. Blood, urine, and spinal fluid were obtained for culture and counterimmunoelectrophoresis. Dextrose was administered to each patient to maintain glucose levels in the normal range. Dextrose infusion rates were calculated in milligrams per kilogram per minute. Of the 29 infants, 6 had sepsis (positive culture and counterimmunoelectrophoresis results). Infants with sepsis had significant elevations of plasma lactate concentration (p0.003) but normal pH. The dextrose infusion rate was also significantly elevated in the infected infants (p0.01). No hypoglycemia or hyperglycemia was observed in either group. No significant difference in plasma insulin concentration was observed. We conclude that significant elevations in plasma lactate concentrations and dextrose infusion rate may be early clinical markers of neonatal sepsis in the first 48 hours of life. |
| Databáze: | OpenAIRE |
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