Eotaxin-2 as a potential marker of preterm premature rupture of membranes: A prospective, cohort, multicenter study
| Autor: | Piotr Laudański, Grzegorz Raba, Marian Kacerovsky |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Eotaxin
Fetal Membranes Premature Rupture medicine.medical_specialty Preterm labor medicine.medical_treatment Medicine (miscellaneous) Inflammation Gastroenterology General Biochemistry Genetics and Molecular Biology Cohort Studies Pregnancy Internal medicine Internal Medicine Humans Medicine Pharmacology (medical) Prospective Studies Stage (cooking) Prospective cohort study Genetics (clinical) business.industry Chemokine CCL24 Infant Newborn medicine.disease Cytokine Reviews and References (medical) Female medicine.symptom business Premature rupture of membranes Biomarkers |
| Zdroj: | Advances in Clinical and Experimental Medicine. 30:197-202 |
| ISSN: | 1899-5276 |
| DOI: | 10.17219/acem/130609 |
| Popis: | Background Despite advances in medicine, there is currently no effective procedure for predicting and the early diagnosis of preterm premature rupture of membranes (pPROM). Objectives To apply measurements of selected biochemical markers of inflammation for diagnosing cases of pPROM without clinical signs of infection. Material and methods This is a prospective cohort study. Three groups were compared, a study group: 82 women between 22 and 37 weeks of pregnancy hospitalized due to pPROM, a control group: 64 women between 22 and 37 weeks of pregnancy in the 1st stage of preterm labor with intact fetal membranes, and a reference group: 99 women between 37 and 42 weeks of pregnancy in the 1st stage of physiological term labor and intact fetal membranes. To assess the concentration of cytokines, a multiplex method was used for measurement of: IGFBP-1, IGFBP-2, BDNF, L-selectin, E-selectin, PECAM-1, ICAM-1, and VCAM-1, MIP-1d, MIP-3b, BLC, eotaxin-1, and eotaxin-2. Results Out of the studied molecules, we found that eotaxin-2 concentrations in the study group were significantly lower than in the control group and the reference group: 9.22 pg/mL compared to 13.76 pg/mL and 14.14 pg/mL (p = 0.014), respectively. We also showed that serum concentration of eotaxin-2 below 8.24 pg/mL could be used as a cut-off level of pPROM (sensitivity: 0.58; specificity: 0.57). Conclusions Findings of significant differences in eotaxin-2 can be the basis for further studies on the use of this molecule as a biochemical marker of pPROM. |
| Databáze: | OpenAIRE |
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