Improved synthesis of antibacterial 3-substituted 6-anilinouracils

Autor:	Kerstin Ehlert, Niels Svenstrup, Alexander Kuhl, Dieter Habich
Rok vydání:	2008
Předmět:	Stereochemistry Gram-positive bacteria Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Gram-Positive Bacteria Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Enzyme Inhibitors Uracil Molecular Biology Polymerase DNA Polymerase III Antibacterial agent chemistry.chemical_classification Aniline Compounds Molecular Structure biology Organic Chemistry Aromatic amine biology.organism_classification Combinatorial chemistry Anti-Bacterial Agents Enzyme chemistry biology.protein Molecular Medicine Derivative (chemistry) Bacteria
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:3215-3218
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2008.04.061
Popis:	3-Substituted 6-anilinouracils, presently the most promising class of inhibitors of the bacterial DNA polymerase in Gram-positive bacteria, have been prepared by a general and straightforward three-step procedure starting from a readily available 1-benzyloxymethyl-protected derivative of 6-chlorouracil.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8e7875b85d2d5c59f82498a45e0e0c https://doi.org/10.1016/j.bmcl.2008.04.061 Zobrazit plný text záznamu Full Text from ScienceDirect