FOXP3 transcription factor: a candidate marker for susceptibility and prognosis in triple negative breast cancer
| Autor: | Karen Brajão de Oliveira, Carolina Batista Ariza, Alda Losi Guembarovski, Roberta Losi Guembarovski, Marina Okuyama Kishima, Julie Massayo Maeda Oda, Leandra Fiori Lopes, Maria Angelica Ehara Watanabe, Clodoaldo Zago Campos, Sueli Donizete Borelli |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Article Subject medicine.drug_class lcsh:Medicine Breast Neoplasms Biology General Biochemistry Genetics and Molecular Biology law.invention law medicine Biomarkers Tumor Humans Genetic Predisposition to Disease Receptor Transcription factor Triple-negative breast cancer Polymerase chain reaction Polymorphism Genetic General Immunology and Microbiology lcsh:R FOXP3 Forkhead Transcription Factors General Medicine Middle Aged Phenotype Gene Expression Regulation Neoplastic Estrogen Cancer research Immunohistochemistry Female Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 |
| Popis: | Triple negative breast cancer (TNBC) is a relevant subgroup of neoplasia which presents negative phenotype of estrogen and progesterone receptors and has no overexpression of the human epidermal growth factor 2 (HER2). FOXP3 (forkhead transcription factor 3) is a marker of regulatory T cells (Tregs), whose expression may be increased in tumor cells. This study aimed to investigate a polymorphism (rs3761548) and the protein expression of FOXP3 for a possible involvement in TNBC susceptibility and prognosis. Genetic polymorphism was evaluated in 50 patients and in 115 controls by allele-specific PCR (polymerase chain reaction). Protein expression was evaluated in 38 patients by immunohistochemistry. It was observed a positive association for homozygous AA (OR = 3.78; 95% CI = 1.02–14.06) in relation to TNBC susceptibility. Most of the patients (83%) showed a strong staining for FOXP3 protein in the tumor cells. In relation to FOXP3-positive infiltrate, 47% and 58% of patients had a moderate or intense intratumoral and peritumoral mononuclear infiltrate cells, respectively. Tumor size was positively correlated to intratumoral FOXP3-positive infiltrate (P=0.026). In conclusion, since FOXP3 was positively associated with TNBC susceptibility and prognosis, it seems to be a promising candidate for further investigation in larger TNBC samples. |
| Databáze: | OpenAIRE |
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