Detection of Avian H7N9 Influenza A Viruses in the Yangtze Delta Region of China During Early H7N9 Outbreaks
| Autor: | Li Yin, Yao-Xing Liu, Xiao-Yan Liu, Richard J. Webby, Li-Ping Long, Chang-Hai Chen, Kong-Wang He, Xiu-Feng Wan, Dong-Min Zhao, Feng Fan, Kai-Kai Han, Jing Yang, Yuzhuo Liu, Xin-Mei Huang, Yifei Xu, Xingxing Xie, You-Fa Zhang |
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| Rok vydání: | 2015 |
| Předmět: |
China
Veterinary medicine viruses Biosecurity Biology Influenza A Virus H7N9 Subtype medicine.disease_cause Article Virus Disease Outbreaks Food Animals Pandemic Influenza A Virus H9N2 Subtype Influenza A virus medicine Animals Phylogeny Poultry Diseases Epizootic General Immunology and Microbiology business.industry Outbreak Poultry farming medicine.disease Virology Influenza A virus subtype H5N1 Ducks Influenza in Birds Animal Science and Zoology business Chickens |
| Zdroj: | Avian Diseases. 60:118 |
| ISSN: | 0005-2086 |
| Popis: | Since the first H7N9 human case in Shanghai, February 19, 2013, the emerging avian-origin H7N9 influenza A virus has become an epizootic virus in China, posing a potential pandemic threat to public health. From April 2 to April 28, 2013, some 422 oral-pharyngeal and cloacal swabs were collected from birds and environmental surfaces at five live poultry markets (LPMs) and 13 backyard poultry farms (BPFs) across three cities, Wuxi, Suzhou, and Nanjing, in the Yangtze Delta region. In total 22 isolates were recovered, and six were subtyped as H7N9, nine as H9N2, four as H7N9/H9N2, and three unsubtyped influenza A viruses. Genomic sequences showed that the HA and NA genes of the H7N9 viruses were similar to those of the H7N9 human isolates, as well as other avian-origin H7N9 isolates in the region, but the PB1, PA, NP, and MP genes of the sequenced viruses were more diverse. Among the four H7N9/H9N2 mixed infections, three were from LPM, whereas the other one was from the ducks at one BPF, which were H7N9 negative in serologic analyses. A survey of the bird trading records of the LPMs and BPFs indicates that trading was a likely route for virus transmission across these regions. Our results suggested that better biosecurity and more effective vaccination should be implemented in backyard farms, in addition to biosecurity management in LPMs. |
| Databáze: | OpenAIRE |
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