Risk Factors Associated with Retinopathy of Prematurity in Very and Extremely Preterm Infants
| Autor: | Emil Radu Iacob, Roxana Iacob, Daniela Iacob, Florina Stoica, Mihai Dinu, Claudia Ioana Borțea, Marioara Boia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Artificial ventilation
medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Medicine (General) genetic structures medicine.medical_treatment Birth weight Gestational Age Gastroenterology Article R5-920 Pregnancy Internal medicine medicine Humans Infant Very Low Birth Weight retinopathy of prematurity risk factors very preterm infants extremely preterm infants Continuous positive airway pressure Retrospective Studies Univariate analysis business.industry Incidence Incidence (epidemiology) Infant Newborn Infant Gestational age preterm birth birth weight Retinopathy of prematurity artificial ventilation General Medicine medicine.disease eye diseases Infant Extremely Premature Breathing Female business |
| Zdroj: | Medicina Volume 57 Issue 5 Medicina, Vol 57, Iss 420, p 420 (2021) |
| ISSN: | 1648-9144 |
| DOI: | 10.3390/medicina57050420 |
| Popis: | Background and Objectives: Retinopathy of prematurity (ROP) is the leading cause of blindness in preterm infants. We studied the relationship between different perinatal characteristics, i.e., sex gestational age (GA) birth weight (BW) C-reactive protein (CRP) and lactate dehydrogenase (LDH) concentrations ventilation, continuous positive airway pressure (CPAP), and surfactant administration and the incidence of Stage 1–3 ROP. Materials and Methods: This study included 247 preterm infants with gestational age (GA) < 32 weeks that were successfully screened for ROP. Univariate and multivariate binary analyses were performed to find the most significant risk factors for ROP (Stage 1–3), while multivariate multinomial analysis was used to find the most significant risk factors for specific ROP stages, i.e., Stage 1, 2, and 3. Results: The incidence of ROP (Stage 1–3) was 66.40% (164 infants), while that of Stage 1, 2, and 3 ROP was 15.38% (38 infants), 27.53% (68 infants), and 23.48% (58 infants), respectively. Following univariate analysis, multiple perinatal characteristics, i.e., GA BW and ventilation, CPAP, and surfactant administration, were found to be statistically significant risk factors for ROP (p < 0.001). However, in a multivariate model using the same characteristics, only BW and ventilation were significant ROP predictors (p < 0.001 and p < 0.05, respectively). Multivariate multinomial analysis revealed that BW was only significantly correlated with Stage 2 and 3 ROP (p < 0.05 and p < 0.001, respectively), while ventilation was only significantly correlated with Stage 2 ROP (p < 0.05). Conclusions: The results indicate that GA and the use of ventilation, CPAP, and surfactant were all significant risk factors for ROP (Stage 1–3), but only BW and ventilation were significantly correlated with ROP and specific stages of the disease, namely Stage 2 and 3 ROP and Stage 2 ROP, respectively, in multivariate models. |
| Databáze: | OpenAIRE |
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