Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics
| Autor: | Shannon L Kordus, Audrey K Thomas, D. Borden Lacy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Diarrhea
General Immunology and Microbiology Clostridioides difficile Fulminant Bacterial Toxins Virulence Inflammation Biology medicine.disease Microbiology Article Infectious Diseases Bacterial Proteins Immunology Tissue damage medicine Humans Antitoxins medicine.symptom Colitis Antitoxin Clostridioides |
| Zdroj: | Nat Rev Microbiol |
| ISSN: | 1740-1534 1740-1526 |
| Popis: | Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium produces up to three toxins, which are considered the major virulence factors in C. difficile infection. These toxins promote inflammation, tissue damage and diarrhoea. In this Review, we highlight recent biochemical and structural advances in our understanding of the mechanisms that govern host-toxin interactions. Understanding how C. difficile toxins affect the host forms a foundation for developing novel strategies for treatment and prevention of C. difficile infection. |
| Databáze: | OpenAIRE |
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