Facilitation of female rat lordosis behavior by hypothalamic infusion of 5-HT2A/2C receptor agonists
| Autor: | Lynda Uphouse, Marjay Caldarola-Pastuszka, Amy Wolf |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Agonist
medicine.medical_specialty Ketanserin Lordosis medicine.drug_class Posture Hypothalamus Middle Pharmacology Sexual Behavior Animal chemistry.chemical_compound Internal medicine medicine Animals Infusions Parenteral Receptor Molecular Biology General Neuroscience Quipazine Amphetamines medicine.disease Lordosis behavior Receptor antagonist Rats Inbred F344 Rats Serotonin Receptor Agonists Endocrinology chemistry Estradiol benzoate Female Serotonin Antagonists Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 779:84-95 |
| ISSN: | 0006-8993 |
| Popis: | Ovariectomized rats were hormonally primed with 0.5 microg estradiol benzoate and 500 microg progesterone to produce two groups of rats differing in their lordosis behavior. Females with a lordosis to mount (L/M) ratio0.5 were used to test the hypothesis that 5-HT(2A/2C) receptor agonists could facilitate lordosis behavior. Females with L/M ratiosor = 0.5 were used to evaluate the potential suppressive effect of 5-HT(2A/2C) receptor compounds. Lordosis behavior was examined following bilateral infusion of drugs into the ventromedial nucleus of the hypothalamus (VMN). Drugs examined were the 5-HT(2A/2C) receptor agonist, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI), the 5-HT(2A/2C) receptor antagonist, 3-[2-[4-(4-fluorobenzoyl)-1-piperdinyl]ethyl]-2,4(1H,3H)-quinazoli nedione tartrate (ketanserin tartrate), and the non-selective 5-HT receptor agents, 2-(1-piperazinyl)quinoline dimaleate (quipazine) and N-(3-trifluoromethylphenyl)piperazine HCl (TFMPP). Drugs with agonist action at 5-HT(2A/2C) receptors increased lordosis behavior in rats with low sexual receptivity. The 5-HT(2A/2C) receptor antagonist, ketanserin, inhibited lordosis behavior in sexually receptive rats. DOI attenuated the lordosis-inhibiting effect of ketanserin, but ketanserin was less effective in preventing DOI from increasing lordosis behavior. These results strengthen prior inferences that activation of 5-HT(2A/2C) receptors can facilitate lordosis behavior and that the VMN is one site at which such facilitation can occur. |
| Databáze: | OpenAIRE |
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