On the Use of a Monilia Vaccine in the Treatment of Sprue
| Autor: | Carl Michel |
|---|---|
| Rok vydání: | 1918 |
| Předmět: | |
| Zdroj: | Journal of Infectious Diseases. 22:53-61 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Sprue has been studied for years and numerous theories as to its etiology have been advanced, but without sufficient proofs to cause their acceptance by workers in tropical medicine. Ashford has devoted much time to the study of this disease, with the result of the discovery of a monilia, which could be isolated from the tongue and feces of sprue patients and also from the tissues of persons dying of the disease. For this monilia he adopted the term Monilia psilosis. The organism and its etiologic relationship to the disease, including the production of sprue symptoms in animals, have been previously described. My studies have been serologic and I have found, using Monilia psilosis antigens, complement fixation in cases of sprue. These cases had been diagnosed and the presence of the monilia determined culturally by Ashford. During the experiments on the toxins of the Monilia psilosis evidence indicating specificity was furnished by the production of immunity in animals. This immunity was produced by the injection of killed cultures, and it was hoped from this that a vaccine might be made having a curative value. |
| Databáze: | OpenAIRE |
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