Moxalactam myoclonus, seizures, and encephalopathy
| Autor: | John M. Bertoni, Leigh Hopkins, Inwha Cho |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Myoclonus Time Factors Myoclonus seizures Encephalopathy 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Seizures Convulsion polycyclic compounds Chronic renal insufficiency Medicine Humans Pharmacology (medical) 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Moxalactam Brain Diseases business.industry Stupor Latamoxef medicine.disease chemistry Anesthesia Female medicine.symptom business |
| Zdroj: | Drug intelligenceclinical pharmacy. 20(3) |
| ISSN: | 0012-6578 |
| Popis: | Severe myoclonus, generalized seizures, and marked stupor occurred in a 39-year-old woman with chronic renal insufficiency after one week of moxalactam 2 g iv q8h. Moxalactam serum levels far exceeded the recommended therapeutic range. The drug half-life was 17 hours (normal 1.9). Excessively high levels of moxalactam, which penetrates the blood-brain-barrier relatively easily, may provoke seizures and encephalopathy. |
| Databáze: | OpenAIRE |
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