Cholinesterase inhibition and toxicologic evaluation of two organophosphate pesticides in Japanese quail
| Autor: | Gordon W. Newell, Jack Barbaccia, Thomas E. Shellenberger, Reginald F. Adams |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Male
medicine.medical_specialty Embryo Nonmammalian media_common.quotation_subject Appetite Toxicology Phosphates Incubation period Birds Fetal Heart Internal medicine biology.animal medicine Animals Pesticides Whole blood media_common Cholinesterase Pharmacology biology Reproduction Body Weight Brain Embryo Body Weight Maintenance biology.organism_classification Quail Fertility Endocrinology biology.protein Coturnix coturnix Female Cholinesterase Inhibitors |
| Zdroj: | Toxicology and Applied Pharmacology. 8:22-28 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(66)90096-2 |
| Popis: | A 5-week toxicologic study of two organophosphate insecticides, Azodrin® and Bidrin®, was undertaken with Japanese quail ( Coturnix coturnix japonica ). Birds fed Azodrin [3-(dimethoxyphosphinyloxy)- N -methyl- cis -crotonamide] at a dietary level of 5 ppm lost weight during the first week, but showed no decrease in egg production or reproduction. At 50 ppm, all females were dead in 2 weeks, and the males in 3 weeks. Whole blood cholinesterase was markedly inhibited at 0.5 ppm, but brain cholinesterase inhibition was marginal. Inhibited cholinesterase demonstrated a marked recovery during a 2-week posttreatment period. Bidrin [3-(dimethoxyphosphinyloxy)- N,N -dimethyl- cis -crotonamide] did not adversely affect body weight maintenance, feed consumption, egg production, or reproduction at 5 ppm in the diet. At 50 ppm, there was marked loss in body weight. Seven males and 9 females died during the 3-week feeding period. Whole blood cholinesterase was almost completely inhibited in both sexes at 0.5 ppm; brain enzyme inhibition was marginal at 5.0 ppm. Normal or near-normal activities of inhibited enzymes were attained during a 2-week recovery period. When fed to adult females, diets containing 0.5 or 5 ppm of either compound caused no adverse effect on the heartbeat of developing embryos throughout the incubation period. |
| Databáze: | OpenAIRE |
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