A new lactam 28-norlimonoid from the leaves of Azadirachta indica A. Juss. (Meliaceae)
| Autor: | Quan L Tran, Nhi Y T Nguyen, Van Thang Nguyen, Phuc Huu Dang, Phu Hoang Dang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Meliaceae
biology 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Plant Science Azadirachta biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Lactam Moiety α glucosidase inhibitory IC50 |
| Zdroj: | Natural Product Research. 33:1903-1908 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | From an EtOAc-soluble fraction of the leaves of Azadirachta indica, one new lactam 28-norlimonoid named nimbandiolactam-21 (1), together with 2 known limonoids (2 and 3) were isolated. Their relative structures were elucidated based on NMR spectroscopic analysis. Nimbandiolactone-23 (2) showed the most potent α-glucosidase inhibitory activity, with an IC50 value of 38.7 μM. Compound 1 represents the first naturally occurring example of a 28-norlimonoid having the lactam moiety. The plausible biosynthetic pathway for the formation of lactam moiety in 1 was proposed. |
| Databáze: | OpenAIRE |
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