Effect of Ingestion of Medium-Chain Triglycerides on Substrate Oxidation during Aerobic Exercise Could Depend on Sex Difference in Middle-Aged Sedentary Persons

Autor: Shougo Tsujino, Naohisa Nosaka, Kazumitsu Honda, Kazuhiko Kato, Kazuo Kondo, Hiromi Suemitsu
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Physiology
Type 2 diabetes
Placebos
0302 clinical medicine
Japan
Medicine
Ingestion
decanoate
Sex Characteristics
Nutrition and Dietetics
Cross-Over Studies
digestive
oral
and skin physiology
fat oxidation
Middle Aged
aerobic exercise
Female
Caprylates
lcsh:Nutrition. Foods and food supply
Oxidation-Reduction
ventilation threshold
Adult
sex difference
030209 endocrinology & metabolism
lcsh:TX341-641
Carbohydrate metabolism
Article
03 medical and health sciences
Oxygen Consumption
sedentary
exercise intensity
Double-Blind Method
Dietary Carbohydrates
Aerobic exercise
Humans
Exercise
Triglycerides
030109 nutrition & dietetics
business.industry
octanoate
Carbohydrate
medicine.disease
Crossover study
Obesity
Dietary Fats
Exercise intensity
Sedentary Behavior
business
Food Science
Zdroj: Nutrients
Volume 13
Issue 1
Nutrients, Vol 13, Iss 36, p 36 (2021)
ISSN: 2072-6643
Popis: Fat oxidation (FAO) during aerobic exercise and whole-body FAO via lipid intake are thought to be important for the maintenance of health, such as the prevention of type 2 diabetes and obesity in sedentary persons in their 40s and 50s. Medium-chain triglycerides (MCTs) ingestion has been attracting attention. However, the effects of difference of sex and the composition of medium-chain fatty acids (MCFAs) are unclear, so we examined the effects of these factors on FAO during aerobic exercise. We conducted a randomized, double-blind, placebo-controlled, 3-arm, within-participants crossover trial. FAO during low- to moderate-intensity exercise was compared when octanoate-rich MCTs (C8R), decanoate-rich MCTs (C10R), or carbohydrate (control) was ingested. Three 2-week interventions were separated by two 2-week washout periods. An increase of FAO during exercise after the C8R diet was found in males, but not in females. An increase of carbohydrate oxidation (CAO) and oxygen uptake during exercise after the C10R diet was found in females, but not in males. In a pooled estimate of the effect of MCTs (C8R and C10R) in women and men, FAO increased during exercise. In conclusion, short-term ingestion of MCTs by middle-aged sedentary persons could increase FAO during aerobic exercise compared to carbohydrate ingestion, but the enhancing effect of MCTs on substrate utilization and oxygen uptake might vary, depending on sex and the composition of MCFAs.
Databáze: OpenAIRE
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