The angiotensinogen gene polymorphism, lifestyle factors, associated diseases and gastric areas of inflammatory and preneoplastic lesions in a Romanian sample of patients
| Autor: | Simona Mocan, Anca Negovan, George-Andrei Crauciuc, Florin Tripon, Mădălina Anciuc |
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| Rok vydání: | 2019 |
| Předmět: |
Gastric areas
business.industry lifestyle factors 03 medical and health sciences 0302 clinical medicine Lifestyle factors agt gene polymorphism Polymorphism (computer science) 030220 oncology & carcinogenesis parasitic diseases Immunology Angiotensinogen gene extension of gastric lesions Medicine 030211 gastroenterology & hepatology business |
| Zdroj: | Romanian Journal of Laboratory Medicine, Vol 27, Iss 4, Pp 401-411 (2019) |
| ISSN: | 2284-5623 |
| Popis: | The aim of our study was to evaluate the association between variant genotype of angiotensinogen (AGT) c.-58A>C, lifestyle factors and clinical factors and corporeal extension of gastric inflammatory and preneoplastic lesions. Methods: Our study included 209 subjects who underwent a complete set of gastric biopsies, followed by genotyping. They were included to study inflammatory gastric changes and preneoplastic lesions and were grouped according to the localization of changes. Results: No significant statistical associations were noticed between AGT c.-58A>C genotypes and the corporeal extension of the inflammation or preneoplastic injury groups. Extending preneoplastic lesions to the gastric body was associated with smoking habits (p=0.01) and additionally, there was a significant association between nicotine consumption and the body extension of preneoplastic lesions (p=0.01). The use of acenocoumarol was frequently associated with the progression of histological lesions to preneoplastic lesions (p=0.01). Compared with the wild-type AA genotype, the combined genotypes AA+CC of AGT c.-58A>C were significantly associated with the progression of inflammatory gastric lesions’ according to the regular ingested doses of nonsteroidal anti-inflammatory drugs (NSAIDs). Conclusion: The AGT c.-58A>C polymorphism is not associated with extension of the gastric lesions. In accordance with nicotine and alcohol consumption, the acenocoumarol co-treatment and multiple cardiac pathologies are associated with the corporeal progression of these injuries. The age below 70 years and NSAIDs treatment for the patients with heterozygous AC genotype and variant homozygous CC genotype for the mentioned SNP have been associated with the corporeal extension of gastric inflammation. |
| Databáze: | OpenAIRE |
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