Prenatal thalamic waves regulate cortical area size prior to sensory processing
| Autor: | Noelia Antón-Bolaños, Miguel Valdeolmillos, Olivier Schaad, Rafael Susín, Michael Rutlin, Henrik Gezelius, Takuji Iwasato, Anton Filipchuk, Cecilia Mezzera, Verónica Moreno-Juan, Guillermina López-Bendito, Luis Rodríguez-Malmierca, Belén Andrés, Sebastien Ducret, Sacha B. Nelson, Filippo M. Rijli, Roland Schüle |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Sensory processing medicine.medical_treatment Science Thalamus Gene Expression General Physics and Astronomy Mice Transgenic Sensory system Biology Somatosensory system Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Pregnancy Cortex (anatomy) Neuroplasticity medicine Animals Humans Vision Ocular Ventral Thalamic Nuclei Neuronal Plasticity Multidisciplinary Gap Junctions Somatosensory Cortex General Chemistry Anatomy Orphan Nuclear Receptors Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Cerebral cortex Calcium Female Nucleus Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | The cerebral cortex is organized into specialized sensory areas, whose initial territory is determined by intracortical molecular determinants. Yet, sensory cortical area size appears to be fine tuned during development to respond to functional adaptations. Here we demonstrate the existence of a prenatal sub-cortical mechanism that regulates the cortical areas size in mice. This mechanism is mediated by spontaneous thalamic calcium waves that propagate among sensory-modality thalamic nuclei up to the cortex and that provide a means of communication among sensory systems. Wave pattern alterations in one nucleus lead to changes in the pattern of the remaining ones, triggering changes in thalamic gene expression and cortical area size. Thus, silencing calcium waves in the auditory thalamus induces Rorβ upregulation in a neighbouring somatosensory nucleus preluding the enlargement of the barrel-field. These findings reveal that embryonic thalamic calcium waves coordinate cortical sensory area patterning and plasticity prior to sensory information processing. How sensory maps are formed in the brain is only partially understood. Here the authors describe spontaneous calcium waves that propagate across different sensory nuclei in the embryonic thalamus; disrupting the wave pattern triggers thalamic gene expression changes and eventually alters the size of cortical areas. |
| Databáze: | OpenAIRE |
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