Effect of CYP1A1 gene polymorphism and psychological distress on seminal analysis parameters
| Autor: | Bidhan Chandra Koner, Aditi Singh, Sudha Prasad, Prakash Chandra Ray, Vijay Kumar Singh, Mirza Masroor, Elvia Jamatia |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Genotype media_common.quotation_subject Physiology Fertility Psychological distress Male infertility 03 medical and health sciences Young Adult 0302 clinical medicine Polymorphism (computer science) Sperm characteristics Obstetrics and Gynaecology Cytochrome P-450 CYP1A1 Medicine Humans Genetic Predisposition to Disease Depression (differential diagnoses) Infertility Male media_common Gynecology Psychiatric Status Rating Scales 030219 obstetrics & reproductive medicine Polymorphism Genetic Sperm Count business.industry Research Obstetrics and Gynecology respiratory system medicine.disease Sperm Spermatozoa Semen Analysis CYP1A1 polymorphism Distress 030104 developmental biology Reproductive Medicine Sperm Motility Anxiety Gene polymorphism medicine.symptom business Stress Psychological |
| Zdroj: | Reproductive Health |
| ISSN: | 1742-4755 |
| DOI: | 10.1186/s12978-016-0169-1 |
| Popis: | Background Psychological factor alters fertility hormones and contributes to male infertility. Anxiety and depression are common manifestations of psychological distress. Cytochrome P-4501A1 (CYP1A1) metabolizes xenobiotics and fertility hormones that influence male fertility. The effect of CYP1A1 polymorphism on male fertility has remained controversial. The present study was designed to assess the effect of psychological distress and CYP1A1 polymorphisms and their interactions on parameters of seminal analysis. Methods Eighty male partners of infertile couples were evaluated for level of distress using Hospital anxiety and depression score (HADS) questionnaire. As per WHO guidelines (2010), sperm count, motility and morphology were assessed and subjects were classified as (a) subjects having normal sperm characteristics and (b) subjects having abnormal sperm characteristics. CYP1A1 polymorphisms were detected by ASO-PCR. Results The significant odd’s ratio indicates that psychological distress (OR:10.54; CI:3.72–29.84; P |
| Databáze: | OpenAIRE |
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