Clinical presentation, convalescence, and relapse of rocky mountain spotted fever in dogs experimentally infected via tick bite
| Autor: | Jana M. Ritter, Michael Levin, Galina E. Zemtsova, Lindsay F. Killmaster, Gregory Langham |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Rocky Mountain spotted fever Rickettsia rickettsii lcsh:Medicine Serology Recurrence Medicine Dog Diseases Rickettsia lcsh:Science Rocky Mountain Spotted Fever media_common Doxycycline Mammals Multidisciplinary biology Convalescence Prognosis Rash Anti-Bacterial Agents Bacterial Pathogens Medical Microbiology Vertebrates medicine.symptom Veterinary Pathology medicine.drug Research Article Veterinary Medicine media_common.quotation_subject Tick Microbiology Veterinary Immunology Dogs Animals Microbial Pathogens Tick Bites Bacteria business.industry lcsh:R Organisms Biology and Life Sciences medicine.disease biology.organism_classification Neutrophilia Disease Models Animal Immunology lcsh:Q Veterinary Science business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 12, p e115105 (2014) |
| ISSN: | 1932-6203 |
| Popis: | Rocky Mountain spotted fever (RMSF) is a tick-borne disease caused by R. rickettsii in North and South America. Domestic dogs are susceptible to infection and canine RMSF can be fatal without appropriate treatment. Although clinical signs of R. rickettsii infection in dogs have been described, published reports usually include descriptions of either advanced clinical cases or experimental infections caused by needle-inoculation of cultured pathogen rather than by tick bite. The natural progression of a tick-borne R. rickettsii infection has not been studied in sufficient detail. Here, we provide a detailed description of clinical, hematological, molecular, and serological dynamics of RMSF in domestic dogs from the day of experimental exposure to infected ticks through recovery. Presented data indicate that neither the height/duration of fever nor detection of rickettsial DNA in dogs' blood by PCR are good indicators for clinical prognosis. Only the apex and subsequent subsidence of neutrophilia seem to mark the beginning of recovery and allow predicting a favorable outcome in Rickettsia-infected dogs, even despite the continuing persistence of mucosal petechiae and skin rash. On the other hand the appropriate (doxycycline) antibiotic therapy of sufficient duration is crucial in prevention of RMSF relapses in dogs. |
| Databáze: | OpenAIRE |
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