A randomized, double blind study of the prophylactic effect of hyperbaric oxygen therapy on migraine
Autor: | Stian Lydersen, Alf O. Brubakk, Lars Jacob Stovner, Olav Sande Eftedal, Grethe Helde, Linda R. White |
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Rok vydání: | 2004 |
Předmět: |
Adult
Male Hyperbaric oxygenation Migraine Disorders Double blind study Double blind 03 medical and health sciences 0302 clinical medicine Hyperbaric oxygen Medicine Humans 030212 general & internal medicine Aged Hyperbaric Oxygenation Endothelin-1 business.industry General Medicine Venous blood Middle Aged medicine.disease Migraine Anesthesia Female Neurology (clinical) business 030217 neurology & neurosurgery After treatment |
Zdroj: | Cephalalgia : an international journal of headache. 24(8) |
ISSN: | 0333-1024 |
Popis: | In a double blind, placebo-controlled study to assess the prophylactic effect of hyperbaric oxygen therapy on migraine, 40 patients were randomly assigned to a treatment group receiving three sessions of hyperbaric oxygen, or a control group receiving three hyperbaric air treatments. The patients were instructed to keep a standardized migraine diary for eight weeks before and after the treatment. Thirty-four patients completed the study. Our primary measure of efficacy was the difference between pre- and post-treatment hours of headache per week. The results show a nonsignificant reduction in hours of headache for the hyperbaric oxygen group compared to the control group. Levels of endothelin-1 in venous blood before and after treatment did not reveal any difference between the hyperbaric oxygen and control groups. We conclude that the tested protocol does not show a significant prophylactic effect on migraine and does not influence the level of endothelin-1 in venous blood. |
Databáze: | OpenAIRE |
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