Age-related changes in brain microanatomy: sensitivity to treatment with the dihydropyridine calcium channel blocker darodipine (PY 108-068)
Autor: | J.A. Vega, Francesco Amenta, F.J. Naves, Miguel Del Valle, M Mancini, Daniela Cavallotti, Yong-Chun Zeng |
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Rok vydání: | 1995 |
Předmět: |
Male
medicine.medical_specialty Aging Nifedipine Central nervous system Hippocampus Biology Lipofuscin chemistry.chemical_compound Cortex (anatomy) Internal medicine medicine Animals Tissue Distribution Rats Wistar Darodipine Neurons General Neuroscience Dihydropyridine Brain Alkaline Phosphatase Calcium Channel Blockers Rats medicine.anatomical_structure Endocrinology chemistry Cerebral cortex Cerebellar cortex medicine.drug |
Zdroj: | Brain research bulletin. 36(5) |
ISSN: | 0361-9230 |
Popis: | The influence of aging and of treatment with the dihydropyridine Ca2+ antagonist darodipine (PY 108-068) on the age-related microanatomical changes of rat brain were studied in male Wistar rats treated from the 18th to the 24th month of age with an oral dose of 5 mg/kg/day of darodipine. Twelve-month-old untreated rats were used as an adult reference group. A decreased number of nerve cells and of alkaline phosphatase-positive capillaries and an increased lipofuscin deposition were observed in the frontal and occipital cortex, in the hippocampus, and in the cerebellar cortex of rats of 24 months in comparison with 12-month-old animals. The number of nerve cells was higher in the occipital cortex and in the hippocampus, but not in the frontal cortex and in the cerebellar cortex, of darodipine-treated rats in comparison with age-matched untreated animals. Lipofuscin deposition is reduced in all the brain areas investigated. The density of alkaline phosphatase-reactive capillaries is also increased in the frontal and occipital cortex and in the hippocampus of aged rats treated with darodipine. The above results suggest that treatment with darodipine is able to counter some microanatomical changes occurring in the brain of aged rats and involving not only microvascular parameters. The occipital (visual) cortex and the hippocampus were the cerebral areas more sensitive to treatment with darodipine. The possible relevance of these findings is discussed. |
Databáze: | OpenAIRE |
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