B-vitamin Mixture Improves the Analgesic Effect of Diclofenac in Patients with Osteoarthritis: A Double Blind Study
| Autor: | Héctor I. Rocha-González, C. Fernández del Valle-Laisequilla, Vinicio Granados-Soto, M. C. Magaña-Villa, Miriam del Carmen Carrasco-Portugal, Juan Gerardo Reyes-García, Francisco J. Flores-Murrieta, Juan Rodríguez-Silverio |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Diclofenac Visual analogue scale Analgesic Osteoarthritis law.invention Double-Blind Method Randomized controlled trial law Drug Discovery Humans Medicine Aged Analgesics business.industry Drug Synergism General Medicine Diclofenac Sodium Middle Aged medicine.disease stomatognathic diseases B vitamins Anesthesia Vitamin B Complex Female Intramuscular injection business medicine.drug |
| Zdroj: | Drug Research. 63:289-292 |
| ISSN: | 2194-9387 2194-9379 |
| DOI: | 10.1055/s-0033-1334963 |
| Popis: | According to the high consumption of the mixture of B vitamins and diclofenac in several countries, this combination has constituted a frequently used option in pain therapy from inflammatory origin. Although the evidence obtained from inflammatory pain animal models has shown the existence of analgesic synergy between diclofenac and the B vitamins mixture, the corresponding clinical evidence is scarce. A double-blind, randomized clinical trial study was designed to characterize the analgesic effect and safety of diclofenac and B vitamins against diclofenac alone in patients with severe osteoarthritis. Forty eight patients programmed to total knee arthroplasty with a pain level ≥7 in a 1-10 cm visual analogue scale were allocated to receive a single intramuscular injection of sodium diclofenac (75 mg) alone or combined with thiamine (100 mg), pyridoxine (100 mg) and cyanocobalamin (5 mg), and the pain level was evaluated during 12 h post-injection. Diclofenac+B vitamins mixture showed a superior analgesic effect during the assessed period and also a better assessment of the pain relief perception by patients than diclofenac alone. This study constitutes a clinical support on the improvement of the analgesic effect of diclofenac by B vitamins in patients with osteoarthritis programmed to total knee arthroplasty, as a clinical model of inflammatory pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|