High expression of heparanase-2 is an independent prognostic parameter for favorable survival in gastric cancer patients
Autor: | Xiaogang Zhang, Shu Xu, Longgen Liu, Qinxiang Tan |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Epidemiology Immunoenzyme Techniques chemistry.chemical_compound Western blot Stomach Neoplasms Molecular marker Internal medicine Biomarkers Tumor Humans Medicine Neoplasm Invasiveness HEPARANASE 2 Survival rate Aged Neoplasm Staging Polysaccharide-Lyases Tissue microarray medicine.diagnostic_test business.industry Cancer Middle Aged Prognosis medicine.disease Survival Rate Exact test chemistry Tissue Array Analysis Lymphatic Metastasis Immunohistochemistry Female business Follow-Up Studies |
Zdroj: | Cancer Epidemiology. 37:1010-1013 |
ISSN: | 1877-7821 |
DOI: | 10.1016/j.canep.2013.09.012 |
Popis: | Heparanase-2 expression has been suggested to up-regulate in several types of human cancers. However, the expression patterns of heparanase-2 in gastric cancer and its effect on prognosis of gastric cancer patients are unclear.In this study, the methods of tissue microarray, immunohistochemistry (IHC), and western blot were used to investigate heparanase-2 expression in gastric cancer and the adjacent non-cancerous tissues. Heparanase-2 expression was analyzed by immunohistochemistry in 95 clinicopathologically characterized gastric cancer cases. In addition Fisher's exact test, Kaplan-Meier plots and Cox proportional hazards regression model were used to analyze the results.High expression of cytoplasmic heparanase-2 was observed in 70.5% (67/95) of gastric cancer, when compared with its normal counterpart. Overexpression of heparanase-2 was correlated with tumor size and differentiation (P0.05). Further analysis showed that a significant correlation between high expression of heparanase-2 and favorable prognosis (P0.05). In multivariate analysis, high expression of heparanase-2 was evaluated as an independent prognostic factor in gastric cancer (P0.05).Our data suggest for the first time that the high expression of heparanase-2 is associated significantly with tumor growth and differentiation. Importantly, heparanase-2 may be a potential molecular marker for predicting prognosis of gastric cancer. |
Databáze: | OpenAIRE |
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