The mitochondrial calcium uniporter: a new therapeutic target for Parkinson's disease-related cardiac dysfunctions?
| Autor: | José Gustavo Patrão Tavares, Paolo Ruggero Errante, Fulvio A. Scorza, Henrique Ballalai Ferraz, Afonso Caricati-Neto, Efrain Olszewer, Josef Finsterer, Francisco Sandro Menezes-Rodrigues, Carla A. Scorza |
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| Rok vydání: | 2020 |
| Předmět: |
Medicine (General)
Parkinson's disease Heart Diseases education Disease 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences R5-920 0302 clinical medicine Paralysis medicine Homeostasis Humans 030212 general & internal medicine business.industry Parkinson Disease Mitochondrial calcium uniporter General Medicine medicine.disease Shaking palsy Editorial Calcium Calcium Channels medicine.symptom business |
| Zdroj: | Clinics; v. 75 (2020); e1299 Clinics; Vol. 75 (2020); e1299 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 75, Article number: e1299, Published: 10 JAN 2020 |
| ISSN: | 1807-5932 1980-5322 |
| Popis: | In 1817, the London surgeon and pharmacist James Parkinson published a 66-page-long booklet entitled “An Essay on the Shaking Palsy”, which contains the first detailed, clinical description of the shaking palsy, or “paralysis agitans”, which is currently known as Parkinson’s disease (PD) (). Two important facts James Parkinson probably did not consider at that time include the scientific progress of neuroscience over the past two centuries and the changes in the world’s population aging since then (). In fact, the [...] |
| Databáze: | OpenAIRE |
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