Neuroprotection care bundle implementation is associated with improved long-term neurodevelopmental outcomes in extremely premature infants

Autor: Amina Benlamri, Prashanth Murthy, Hussein Zein, Sumesh Thomas, James N. Scott, Ayman Abou Mehrem, Michael J. Esser, Abhay Lodha, Jennessa Noort, Selphee Tang, Cathy Metcalfe, Derek Kowal, Leigh Irvine, Jillian Scotland, Lara M. Leijser, Khorshid Mohammad
Rok vydání: 2022
Předmět:
Zdroj: Journal of Perinatology. 42:1380-1384
ISSN: 1476-5543
0743-8346
Popis: To study the impact of an evidence-based neuroprotection care (NPC) bundle on long-term neurodevelopmental impairment (NDI) in infants born extremely premature.An NPC bundle targeting predefined risk factors for acute brain injury in extremely preterm infants was implemented. We compared the incidence of composite outcome of death or severe neurodevelopmental impairment (sNDI) at 21 months adjusted age pre and post bundle implementation.Adjusting for confounding factors, NPC bundle implementation associated with a significant reduction in death or sNDI (aOR, 0.34; 95% CI 0.17-0.68; P = 0.002), mortality (aOR, 0.31; 95% CI (0.12-0.79); P = 0.015), sNDI (aOR, 0.37; 95% CI: 0.12-0.94; P = 0.039), any motor, language, or cognitive composite scorelt;70 (aOR, 0.48; 95% CI: 0.26-0.90; P = 0.021).Implementation of NPC bundle targeting predefined risk factors is associated with a reduction in mortality or sNDI in extremely preterm infants.
Databáze: OpenAIRE
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