The role of cyclooxygenase-2 (COX-2) in breast cancer, and implications of COX-2 inhibition
| Autor: | Kefah Mokbel, G. Singh-Ranger |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Mammary gland Antineoplastic Agents Breast Neoplasms Disease medicine.disease_cause Isozyme Prostaglandin-endoperoxide synthase 2 Pathogenesis Mice chemistry.chemical_compound Breast cancer Internal medicine Tumor Cells Cultured medicine Animals Humans Cyclooxygenase Inhibitors Enzyme Inhibitors Cyclooxygenase 2 Inhibitors biology business.industry Anti-Inflammatory Agents Non-Steroidal Membrane Proteins General Medicine medicine.disease Rats Isoenzymes Cell Transformation Neoplastic Endocrinology medicine.anatomical_structure Oncology chemistry Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Models Animal Cyclooxygenase 1 biology.protein Cancer research Female Surgery Cyclooxygenase business Carcinogenesis |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 28:729-737 |
| ISSN: | 0748-7983 |
| DOI: | 10.1053/ejso.2002.1329 |
| Popis: | The cyclooxygenase (COX) enzyme system is composed of two isoenzymes, COX-1 and COX-2. Recent sources of experimental and epidemiological evidence suggest a significant role for the COX enzymes, particularly COX-2, in the pathogenesis of breast cancer. This has important implications for treatment of the disease. This article reviews the evidence for a relationship between the COX enzyme system and mammary carcinogenesis, and discusses the likely therapeutic roles and potential pitfalls of COX inhibition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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