Synthesis of functionalized nitrogen heterocycles from β- and γ-amino acids by radical decarboxylation

Autor:	Rosendo Hernández, Yolanda León, José Ramón Murguía, Alicia Boto, Abigail Rodríguez-Afonso
Přispěvatelé:	Ministerio de Ciencia y Tecnología (España), European Commission, Gobierno de Canarias
Rok vydání:	2004
Předmět:	chemistry.chemical_classification Arylpiperidines Pyrrolidines Decarboxylation Radical Organic Chemistry chemistry.chemical_element Radicals Biochemistry Nitrogen Amino acid Piperidines chemistry Drug Discovery Amino acids Organic chemistry Antifungic
Zdroj:	Digital.CSIC. Repositorio Institucional del CSIC instname
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2004.07.111
Popis:	5 pages, 1 figure, 3 schemes.-- Printed version published Sep 6, 2004. The radical decarboxylation of β- and γ-amino acids on treatment with PhI(OAc)2–I2 is a mild and efficient methodology to synthesize halogenated or oxygenated nitrogen heterocycles. The reaction was applied to the synthesis of bioactive products, such as opioid analogues, iminosugars and new antifungic agents. This work was supported by the Investigation Programmes PPQ2000-0728 and PPQ2003-01379 of the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica, Dirección General de Investigación, Ministerio de Ciencia y Tecnología, Spain. We also acknowledge financial support from FEDER funds. Y.R. thanks Gobierno de Canarias for a fellowship.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7446e2eff16e1d00e3032fd066897b https://doi.org/10.1016/j.tetlet.2004.07.111 Zobrazit plný text záznamu Full Text from ScienceDirect