Association between vascular endothelial growth factor polymorphism and recurrent pregnancy loss: A systematic review and meta-analysis
| Autor: | Chuanxin Xu, Xianping Zhang, Min Chen, Yaling Sun, Xianglin Cheng, Benyu Mao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine Oncology Abortion Habitual medicine.medical_specialty VEGF receptors Bioinformatics Polymorphism Single Nucleotide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Internal medicine medicine Humans Genetic Predisposition to Disease Genetic Association Studies 030219 obstetrics & reproductive medicine biology business.industry Obstetrics and Gynecology Odds ratio medicine.disease Vascular endothelial growth factor Vascular endothelial growth factor A 030104 developmental biology Increased risk Reproductive Medicine chemistry Meta-analysis biology.protein Female Dominant model business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 211:169-176 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2017.03.003 |
| Popis: | Purpose Some studies have reported that vascular endothelial growth factor (VEGF) genetic polymorphisms are associated with recurrent pregnancy loss (RPL), but the results are controversial. This study is aimed to quantify the strength of this association. Methods A systematic review of the published literature from Medline, Springer, and China National Knowledge Infra structure (CNKI) databases was conducted and investigations of VEGF genetic polymorphisms in RPL were selected. We estimated the pooled odds ratio (OR) to assess this possible association. Results Fifteen case-control studies comprising 2702 cases and 2667 controls and including five genetic polymorphisms (rs3025039, rs833061, rs15703060, rs2010963 and rs699947) were eligible for this meta-analysis. The overall analysis suggested that only two genetic polymorphisms (rs1570360, rs3025039) were associated with increased risk of RPL. A significant increased risk between VEGF rs1570360 polymorphism and RPL was only found under the dominant model in Caucasians (OR = 1.70, 95% CI 1.02-2.82, P = 0.04). Whereas, we found that VEGF rs3025039 polymorphism was significantly associated with RPL both under the dominant and recessive model in East Asians, and their summary odd ratios and 95% CIs were 1.26, 1.04-1.53, P = 0.02 and 2.94, 1.80-4.83, P = 0, respectively. Conclusions This meta-analysis showed that only rs1570360 (especially in Caucasians) and rs3025039 (especially in East Asians) may be risk factors for RPL. |
| Databáze: | OpenAIRE |
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