Lack of nephrotoxicity of styrene at current TLV level (50 ppm)
| Autor: | Alfred Bernard, Miloslav Tušl, S. Emminger, Eva Ettlerova, Adolf Vyskočil, Zdenek Fiala, F. Malir |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
medicine.medical_specialty Renal function Urine Styrenes Nephrotoxicity Excretion chemistry.chemical_compound Lactate dehydrogenase Internal medicine medicine Humans Styrene Creatinine Kidney Public Health Environmental and Occupational Health Albumin Middle Aged Occupational Diseases Endocrinology medicine.anatomical_structure chemistry Mandelic Acids Female Kidney Diseases Maximum Allowable Concentration |
| Zdroj: | International Archives of Occupational and Environmental Health. 61:409-411 |
| ISSN: | 1432-1246 0340-0131 |
| DOI: | 10.1007/bf00381033 |
| Popis: | Biochemical markers of kidney damage were examined in 37 female workers exposed to an average concentration of 225 mg/m3 of styrene. The concentration of mandelic acid in urine was on the average 759 mg/g creatinine. The mean duration of employment of the exposed subjects was 11 years. The results were compared to those obtained in 35 control female workers matched for age and a number of demographic and lifestyle factors and with no history of exposure to organic solvents. No difference was found in the urinary excretion of albumin, beta 2-microglobulin, retinol-binding protein, total proteins, glucose, lysozyme, lactate dehydrogenase and beta-N-acetyl-D-glucosaminidase. The present study provides thus further evidence that exposure to styrene at the current TLV (215 mg/m3) does not entail any detectable risk for the renal function. |
| Databáze: | OpenAIRE |
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