Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes
| Autor: | Peter W. Jones, Christopher Luscombe, Mark F. Saxby, Richard C. Strange, S Liu, Anthony A. Fryer, Michael E. French |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male ultraviolet radiation Cancer Research medicine.medical_specialty Genotype Ultraviolet Rays Prostatic Hyperplasia Calcitriol receptor susceptibility polymorphism RC0254 Prostate cancer Gene Frequency Risk Factors Prostate Internal medicine Humans Medicine Genetic Predisposition to Disease Receptor Aged Monophenol Monooxygenase business.industry Receptors Melanocortin Prostatic Neoplasms Cancer Regular Article Environmental Exposure Odds ratio Middle Aged prostate cancer medicine.disease Logistic Models medicine.anatomical_structure Endocrinology Receptors Corticotropin Oncology Case-Control Studies Receptors Calcitriol business Melanocortin 1 receptor |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1054/bjoc.2001.2097 |
| Popis: | Exposure to ultraviolet radiation may reduce prostate cancer risk, suggesting that polymorphism in genes that mediate host pigmentation will be associated with susceptibility to this cancer. We studied 210 prostate cancer cases and 155 controls to determine whether vitamin D receptor (VDR, Taql and Fokl variants), tyrosinase (TYR, codon 192 variant) and melanocortin-1 receptor (MC1R, Arg151Cys, Arg160Trp, Val92Met, Asp294His and Asp84Glu variants) genotypes are associated with risk. UV exposure was determined using a questionnaire. MC1R Arg160/Arg160 homozygotes were at increased risk (P = 0.027, odds ratio = 1.94) while TYR A2/A2 homozygotes were at reduced risk of prostate cancer (P = 0.033, odds ratio = 0.48). These associations remained significant after correction for UV-exposure. Stratification of cases and controls by quartiles of exposure, showed that the protective effect of TYR A1A2 (P = 0.006, odds ratio 0.075) and A2A2 (P = 0.003, odds ratio 0.055) was particularly strong in subjects who had received the greatest exposure. Our data show for the first time, that allelism in genes linked with skin pigment synthesis is associated with prostate cancer risk possibly because it mediates the protective effects of UV. Importantly, susceptibility is associated with an interaction between host predisposition and exposure. © 2001 Cancer Research Campaign http://www.bjcancer.com |
| Databáze: | OpenAIRE |
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