Pregnancy outcome after first trimester exposure to ionizing radiations

Autor: Delphine Beghin, Hubert Ducou Le Pointe, Eléonore Blondiaux, Ferdinand Dhombres, Stéphanie Friszer, Jean-Marie Jouannic, Lucie Guilbaud, Elisabeth Elefant
Přispěvatelé: CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Service de Radiologie [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)
Rok vydání: 2019
Předmět:
Adult
medicine.medical_specialty
Diaphragmatic breathing
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Ionizing radiations
Miscarriage
Ionizing radiation
03 medical and health sciences
0302 clinical medicine
Pregnancy
Radiation
Ionizing
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Fetal exposure
Univariate analysis
Fetal Growth Retardation
030219 obstetrics & reproductive medicine
business.industry
Obstetrics
Pregnancy Outcome
Abnormalities
Drug-Induced
Obstetrics and Gynecology
General Medicine
medicine.disease
3. Good health
Abortion
Spontaneous
Pregnancy Trimester
First
First trimester
Reproductive Medicine
Maternal Exposure
In utero
Prenatal Exposure Delayed Effects
Teratogenesis
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Female
business
Diagnostic radiations
Cohort study
Zdroj: European Journal of Obstetrics & Gynecology and Reproductive Biology
European Journal of Obstetrics & Gynecology and Reproductive Biology, Elsevier, 2019, 232, pp.18-21. ⟨10.1016/j.ejogrb.2018.11.001⟩
ISSN: 0301-2115
DOI: 10.1016/j.ejogrb.2018.11.001
Popis: International audience; OBJECTIVE: To evaluate the effects of ionizing radiation exposure during the first trimester of pregnancy in usual clinical situations.STUDY DESIGN: We conducted a prospective observational cohort study using data collected between 1987 and 2014. This database was authorized by the French "Commission Nationale de l'Informatique et des Libertés". The exposed group consisted of 319 pregnant women exposed to sub diaphragmatic ionizing radiations for diagnostic purposes, during the first trimester of pregnancy, and the control group consisted of 319 pregnant women without any exposure or exposed to non-teratogenic agents. Data on maternal history and radiations exposure were collected on first contact, and pregnancy outcomes were documented at follow-up. An univariate analysis was performed to compare both groups for the main outcomes.RESULTS: Exposure to sub diaphragmatic ionizing radiation for diagnosis purpose (median fetal dose of 3.1 mGy [0.2-130.0]) during the first trimester of pregnancy was not significantly associated with an increased risk of malformations (1.5% vs 1.8%, p = 1.00), miscarriage (7.8% vs 7.2%, p = 0.88), in utero fetal death (0.3% vs 0%, p = 1.00) or fetal growth restriction (5.4% vs 3.5%, p = 0.62).CONCLUSION: Pregnant women exposed to irradiant diagnostic procedures do not present a higher risk of malformations, miscarriage, in utero fetal death or fetal growth restriction and should be reassured, even if the examination focused on the pelvis.
Databáze: OpenAIRE
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