Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats
| Autor: | B. K. H. Tan, Jayapal Manikandan, C.H. Tan, Peter Natesan Pushparaj, H.K. Low |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Drug Evaluation Preclinical Chicory Diabetes Mellitus Experimental Rats Sprague-Dawley chemistry.chemical_compound Diabetes mellitus Internal medicine Cichorium Drug Discovery medicine Animals Hypoglycemic Agents Triglycerides Pancreatic hormone Pharmacology Glucose tolerance test Plants Medicinal biology Triglyceride medicine.diagnostic_test Plant Extracts Insulin food and beverages Glucose Tolerance Test medicine.disease biology.organism_classification Streptozotocin Metformin Rats Cholesterol Endocrinology chemistry Glucose-6-Phosphatase biology.protein Glucose 6-phosphatase medicine.drug |
| Zdroj: | Journal of Ethnopharmacology. 111:430-434 |
| ISSN: | 0378-8741 |
| Popis: | The present study was designed to investigate the hypoglycemic and hypolipidemic properties of an ethanolic extract of Cichorium intybus (CIE) which is widely used in India as a traditional treatment for diabetes mellitus. Male Sprague-Dawley rats aged 9 weeks (160-200 g) were administered with streptozotocin (STZ, 50mg/kg) intraperitoneally to induce experimental diabetes. The Cichorium intybus whole plant was exhaustively extracted with 80% ethanol, concentrated at 40 degrees C using a rotavapor and freeze dried to get powder. Hypoglycemic effects of CIE were observed in an oral glucose tolerance test (OGTT) in which, a dose of 125 mg of plant extract/kg body weight exhibited the most potent hypoglycemic effect. Moreover, daily administration of CIE (125 mg/kg) for 14 days to diabetic rats attenuated serum glucose by 20%, triglycerides by 91% and total cholesterol by 16%. However, there was no change in serum insulin levels, which ruled out the possibility that CIE induces insulin secretion from pancreatic beta-cells. In addition, hepatic glucose-6-phosphatase activity (Glc-6-Pase) was markedly reduced by CIE when compared to the control group. The reduction in the hepatic Glc-6-Pase activity could decrease hepatic glucose production, which in turn results in lower concentration of blood glucose in CIE-treated diabetic rats. In conclusion, our results support the traditional belief that Cichorium intybus could ameliorate diabetic state. |
| Databáze: | OpenAIRE |
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