The effect of taurine and enriched environment on behaviour, memory and hippocampus of diabetic rats
Autor: | Lisiane Silveira Zavalhia, Aryadne Cardoso Machado, Rosane Gomez, Rosalva Thereza Meurer, Fernanda Huf, Lucas Silva Tortorelli, Francine Luciano Rahmeier, Marilda da Cruz Fernandes, Luiza Paul Géa |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Taurine Hippocampus Context (language use) Apoptosis Biology Environment Motor Activity Neuroprotection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Memory Internal medicine Diabetes mellitus Glial Fibrillary Acidic Protein medicine Diabetes Mellitus Animals Rats Wistar Environmental enrichment Behavior Animal Caspase 3 General Neuroscience Dentate gyrus Neurodegeneration Recognition Psychology medicine.disease Rats Disease Models Animal 030104 developmental biology Endocrinology chemistry Neuroglia 030217 neurology & neurosurgery |
Zdroj: | Neuroscience letters. 630 |
ISSN: | 1872-7972 |
Popis: | Diabetes mellitus (DM) has been studied recently as a major cause of cognitive deficits, memory and neurodegenerative damage. Taurine and enriched environment have stood out for presenting neuroprotective and stimulating effects that deserve further study. In this paper, we examined the effects of taurine and enriched environment in the context of diabetes, evaluating effects on behaviour, memory, death and cellular activity. Eighty-eight Wistar rats were divided into 2 groups (E = enriched environment; C = standard housing). Some animals (24/group) underwent induction of diabetes, and within each group, some animals (half of diabetics (D) and half of non-diabetics (ND)/group) were treated for 30 days with taurine (T). Untreated animals received saline (S). In total, there were eight subgroups: DTC, DSC, NDTC, NDSC, DTE, DSE, NDTE and NDSE. During the experiment, short-term memory was evaluated. After 30th day of experiment, the animals were euthanized and was made removal of brains used to immunohistochemistry procedures for GFAP and cleaved caspase-3. As a result, we observed that animals treated with taurine showed better performance in behavioural and memory tasks, and the enriched environment had positive effects, especially in non-diabetic animals. Furthermore, taurine and enriched environment seemed to be able to interfere with neuronal apoptosis and loss of glial cells, and in some instances, these two factors seemed to have synergistic effects. From these data, taurine and enriched environment may have important neurostimulant and neuroprotective effects. |
Databáze: | OpenAIRE |
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