Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases
| Autor: | Beata Sikorska, Anna Ladogana, Isabel Santana, Pawel P. Liberski, Stefan Goebel, Kaj Blennow, Daniela Varges, Aikaterini Karsanidou, Eirini Kanata, Theodoros Sklaviadis, André Karch, Inês Baldeiras, Isidro Ferrer, Daniela Diaz-Lucena, Franc Llorens, Inga Zerr, Ewa Golanska, Tobias Knipper, Raquel Sánchez-Valle, Matthias Schmitz, Peter Hermann, Henrik Zetterberg, Anna Villar-Piqué, Miguel Calero, Olga Calero |
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| Přispěvatelé: | Universitat de Barcelona, Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany. |
| Předmět: |
0301 basic medicine
Male Pathology Epidemiology Disease Gene mutation Creutzfeldt-Jakob Syndrome Prion Diseases 0302 clinical medicine Medicine Demència Degeneració (Patologia) cerebrospinal fluid [Dementia] Health Policy diagnosis [Alzheimer Disease] Degeneration (Pathology) cerebrospinal fluid [Creutzfeldt-Jakob Syndrome] Middle Aged 3. Good health cerebrospinal fluid [Alzheimer Disease] Psychiatry and Mental health Cerebrospinal fluid cerebrospinal fluid [Biomarkers] Female Malalties per prions Frontotemporal dementia medicine.medical_specialty Prion diseases Context (language use) diagnosis [Creutzfeldt-Jakob Syndrome] tau Proteins macromolecular substances Diagnosis Differential 03 medical and health sciences Cellular and Molecular Neuroscience Developmental Neuroscience Alzheimer Disease mental disorders Dementia Humans ddc:610 Vascular dementia Aged business.industry Dementia with Lewy bodies Líquid cefalorraquidi medicine.disease diagnosis [Prion Diseases] diagnosis [Dementia] 030104 developmental biology cerebrospinal fluid [tau Proteins] Neurology (clinical) Geriatrics and Gerontology Differential diagnosis business 030217 neurology & neurosurgery cerebrospinal fluid [Prion Diseases] Biomarkers |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona Alzheimer's and dementia 14(6), 751-763 (2018). doi:10.1016/j.jalz.2017.12.008 Alzheimer's & Dementia |
| Popis: | Introduction Neurofilament light (NFL) levels in the cerebrospinal fluid are increased in several neurodegenerative dementias. However, their diagnostic accuracy in the differential diagnostic context is unknown. Methods Cerebrospinal fluid NFL levels were quantified in nonprimarily neurodegenerative neurological and psychiatric diseases (n = 122), mild cognitive impairment (n = 48), Alzheimer's disease (n = 108), dementia with Lewy bodies/Parkinson's disease dementia (n = 53), vascular dementia (n = 46), frontotemporal dementia (n = 41), sporadic Creutzfeldt-Jakob disease (sCJD, n = 132), and genetic prion diseases (n = 182). Results The highest NFL levels were detected in sCJD, followed by vascular dementia, frontotemporal dementia, dementia with Lewy bodies/Parkinson's disease dementia, Alzheimer's disease, and mild cognitive impairment. In sCJD, NFL levels correlated with cerebrospinal fluid tau and disease duration. NFL levels were able to differentiate sCJD from nonprimarily neurodegenerative neurological and psychiatric diseases (area under the curve = 0.99, 95% confidence interval: 0.99–1) and from the other diagnostic groups showing cognitive impairment/dementia of a non-CJD etiology (area under the curve = 0.90, 95% confidence interval: 0.87–0.92). Compared to nonprimarily neurodegenerative neurological and psychiatric diseases, NFL was also elevated in genetic prion diseases associated with the E200K, V210I, P102L, and D178N prion protein gene mutations. Discussion Increased NFL levels are a common feature in neurodegenerative dementias. |
| Databáze: | OpenAIRE |
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