Targeting calcium transport in ischaemic heart disease
| Autor: | Muthu Periasamy, M.A. Hassan Talukder, Jay L. Zweier |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Calcium Channels L-Type Physiology Myocardial Ischemia Ischemia Reviews chemistry.chemical_element Myocardial Reperfusion Injury Calcium Sodium-Calcium Exchanger Sarcoplasmic Reticulum Calcium-Transporting ATPases Reperfusion therapy Physiology (medical) Internal medicine medicine Humans cardiovascular diseases Calcium metabolism Sodium-calcium exchanger Vascular disease business.industry Biological Transport medicine.disease chemistry Heart failure Circulatory system Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular Research. 84:345-352 |
| ISSN: | 0008-6363 |
| DOI: | 10.1093/cvr/cvp264 |
| Popis: | Ischaemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide. While timely reperfusion of acutely ischaemic myocardium is essential for myocardial salvage, it leads to a unique type of injury known as 'myocardial ischaemia/reperfusion (I/R) injury'. Growing evidence suggests that a defect in myocardial Ca(2+) transport system with cytosolic Ca(2+) overload is a major contributor to myocardial I/R injury. Progress in molecular genetics and medicine in past years has clearly demonstrated that modulation of Ca(2+) handling pathways in IHD could be cardioprotective. The potential benefits of these strategies in limiting I/R injury are vast, and the time is right for challenging in vivo systemic work both at pre-clinical and clinical levels. |
| Databáze: | OpenAIRE |
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