Computational and Experimental Investigation of the Human and D. Melanogaster Dopamine Transporters
| Autor: | Tyler W.E. Steele, Louis J. De Felice |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0303 health sciences
Monoamine transporter Biophysics Transporter Computational biology Biology biology.organism_classification 3. Good health Structure and function 03 medical and health sciences 0302 clinical medicine Monoamine neurotransmitter Biochemistry Dopamine medicine Melanogaster biology.protein 030217 neurology & neurosurgery Function (biology) 030304 developmental biology medicine.drug Dopamine transporter |
| Zdroj: | Biophysical Journal. (2):462a |
| ISSN: | 0006-3495 |
| DOI: | 10.1016/j.bpj.2014.11.2519 |
| Popis: | The existence of a solved structure for a dopamine transporter drastically changes the landscape for investigation of the mechanism of monoamine transporter function. While previous structures for LeuT have shed light on transport mechanisms, and though LeuT shares considerable structural overlap with dDAT, LeuT has no corresponding electrophysiology. The new structure therefore has the advantage of correlating structure and function to help unravel the outstanding mystery of transporters as channels, which has well developed correlates in the ClC class of Cl- channels but no equivalent in monoamine transporters. |
| Databáze: | OpenAIRE |
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