Xbp1 and Brachyury establish an evolutionarily conserved subcircuit of the notochord gene regulatory network
| Autor: | Yushi Wu, Arun Devotta, Diana S José-Edwards, Jamie E Kugler, Lenny J Negrón-Piñeiro, Karina Braslavskaya, Jermyn Addy, Jean-Pierre Saint-Jeannet, Anna Di Gregorio |
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| Rok vydání: | 2021 |
| Předmět: |
Fetal Proteins
X-Box Binding Protein 1 animal structures QH301-705.5 Science Xenopus Notochord gene regulatory network Xenopus Proteins General Biochemistry Genetics and Molecular Biology Morphogenesis Animals Gene Regulatory Networks Biology (General) Ciona robusta C. intestinalis Evolutionary Biology General Immunology and Microbiology General Neuroscience fungi Gene Expression Regulation Developmental General Medicine Brachyury Ciona intestinalis XBP1 Basic-Leucine Zipper Transcription Factors embryonic structures Medicine T-Box Domain Proteins Research Article Developmental Biology |
| Zdroj: | eLife eLife, Vol 11 (2022) |
| ISSN: | 2050-084X |
| Popis: | Gene regulatory networks coordinate the formation of organs and structures that compose the evolving body plans of different organisms. We are using a simple chordate model, the Ciona embryo, to investigate the essential gene regulatory network that orchestrates morphogenesis of the notochord, a structure necessary for the proper development of all chordate embryos. Although numerous transcription factors expressed in the notochord have been identified in different chordates, several of them remain to be positioned within a regulatory framework. Here, we focus on Xbp1, a transcription factor expressed during notochord formation in Ciona and other chordates. Through the identification of Xbp1-downstream notochord genes in Ciona, we found evidence of the early co-option of genes involved in the unfolded protein response to the notochord developmental program. We report the regulatory interplay between Xbp1 and Brachyury, and by extending these results to Xenopus, we show that Brachyury and Xbp1 form a cross-regulatory subcircuit of the notochord gene regulatory network that has been consolidated during chordate evolution. |
| Databáze: | OpenAIRE |
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