Glutathione Reductase Is Associated with the Clinical Outcome of Septic Shock in the Patients Treated Using Continuous Veno-Venous Haemofiltration
| Autor: | Olegs Suba, Anda Grigane, Alise Silova, Andrejs Skesters, Girts Brigis, Dace Trumpika, Regina Baufale, Eva Bormane, Linda Gailite, Aivars Lejnieks, Inara Busmane, Julija Voicehovska, Georgijs Moisejevs |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Medicine (General) medicine.medical_specialty Continuous Renal Replacement Therapy Glutathione reductase medicine.disease_cause Logistic regression Gastroenterology Article Nitric oxide 03 medical and health sciences chemistry.chemical_compound R5-920 0302 clinical medicine Internal medicine medicine Humans oxidative stress Prospective Studies Aged chemistry.chemical_classification continuous veno-venous haemofiltration business.industry Septic shock Glutathione peroxidase 030208 emergency & critical care medicine General Medicine Odds ratio Malondialdehyde medicine.disease Shock Septic Glutathione Reductase chemistry 030220 oncology & carcinogenesis septic shock Female Hemofiltration business Oxidative stress |
| Zdroj: | Medicina Medicina, Vol 57, Iss 689, p 689 (2021) Volume 57 Issue 7 |
| ISSN: | 1648-9144 |
| Popis: | Background and objectives: At present, there is insufficient evidence to support the use of continuous veno-venous haemofiltration (CVVH) in the early treatment of septic shock. This study focuses on the association between survival and different parameters of oxidative stress (RedOx). Thereby, we evaluated whether RedOx markers are associated with the outcome of septic shock in patients under early-initiated CVVH treatment. Materials and Methods: We conducted a prospective observational study of 65 patients with septic shock who started CVVH within 12 h after hospital admission. Blood samples were taken from each patient prior to the start of CVVH. The following RedOx markers were measured: glutathione peroxidase, glutathione reductase (GR), total antioxidant capacity, superoxide dismutase, nitric oxide, malondialdehyde and 4-hydroxynonenal. The odds ratio (OR) was calculated using binary logistic regression and stepwise multivariable regression. Results: The 65 patients had a median age of 66 years and 39 were male. Based on the outcome, the patients were divided into two groups—non-survivors (n = 29) and survivors (n = 36)—and the levels of RedOx markers were compared between them. Of all the markers, only higher GR activity was found to be significantly associated with the fatal outcome 100.3 U/L versus 60.5 U/L, OR = 1.027 (95% CI, 1.010–1.044). Following adjustment for the sequential organ failure assessment score and other parameters, GR activity still presented a significant association with the fatal outcome, OR = 1.020 (95% CI, 1.002–1.038). Conclusions: GR activity is associated with in-hospital fatal outcomes among septic shock patients under early-initiated CVVH treatment. Septic shock patients who have a lower GR activity at hospital admission may have a favourable outcome of the early initiation of CVVH. |
| Databáze: | OpenAIRE |
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