Bivalve molluscs as a unique target group for nanoparticle toxicity
Autor: | Antonio Marcomini, Giulio Pojana, Gabriella Gallo, Caterina Ciacci, Rita Fabbri, Laura Canesi |
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Rok vydání: | 2012 |
Předmět: |
Cellular immunity
Hemocytes media_common.quotation_subject Daphnia magna RAINBOW-TROUT Aquatic Science Oceanography WALLED CARBON NANOTUBES DAPHNIA-MAGNA TITANIUM-DIOXIDE OXIDATIVE STRESS ENGINEERED NANOPARTICLES MYTILUS-EDULIS ONCORHYNCHUS-MYKISS IMMUNE-SYSTEM Animals Internalization Shellfish media_common Mytilus biology Ecology technology industry and agriculture Aquatic animal General Medicine Marine invertebrates Mussel biology.organism_classification Pollution Bivalvia Biophysics Nanoparticles Water Pollutants Chemical |
Zdroj: | Marine Environmental Research. 76:16-21 |
ISSN: | 0141-1136 |
Popis: | Due to the continuous development and production of manufactured nanomaterials or nanoparticles (NPs), their uptake and effects in the aquatic biota represent a major concern. Estuarine and coastal environments are expected to represent the ultimate sink for NPs, where their chemical behavior (aggregation/agglomeration) and consequent fate may be critical in determining the biological impact. Bivalve mollusks are abundant from freshwater to marine ecosystems, where they are widely utilized in biomonitoring of environmental perturbations. As suspension-feeders, they have highly developed processes for cellular internalization of nano- and micro-scale particles (endo- and phagocytosis), integral to key physiological functions such as intra-cellular digestion and cellular immunity. Here we will summarise available information on the effects of different types of NPs in different bivalve species, in particular Mytilus spp. Data on the effects and modes of action of different NPs on mussel hemocytes in vitro demonstrate that cell-mediated immunity represents a significant target for NPs. Moreover, in vivo exposure to NPs indicates that, due to the physiological mechanisms involved in the feeding process, NP agglomerates/aggregates taken up by the gills are directed to the digestive gland, where intra-cellular uptake of nanosized materials induces lysosomal perturbations and oxidative stress. Overall, bivalves represent a particularly suitable model for investigating the effects and mechanisms of action underlying the potential toxicity of NPs in marine invertebrates. |
Databáze: | OpenAIRE |
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