Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen

Autor:	Robert R. Flavell, Niranjan Meher, Michael J. Evans, Suchi Dhrona, Xiao Huang, Kyounghee Seo, Anil Parsram Bidkar, Tomoko Ozawa, David R. Raleigh, Henry F. VanBrocklin, Young-wook Jun, Ryan Tang, David M. Wilson, Charles Blaha, Sinan Wang, Miko Fogarty, Tejal A. Desai
Rok vydání:	2021
Předmět:	inorganic chemicals Boron Compounds Male Materials science Theranostic nanoparticles Nanoparticle Mice Nude Antineoplastic Agents Boron Neutron Capture Therapy Deferoxamine urologic and male genital diseases Theranostic Nanomedicine Polyethylene Glycols Cell membrane Mice Glutamate carboxypeptidase II medicine Tumor Cells Cultured Animals Humans General Materials Science Polyglactin 910 Membrane antigen Molecular Structure Prostatic Neoplasms Prostate-Specific Antigen Cancer treatment medicine.anatomical_structure Positron-Emission Tomography PC-3 Cells Cancer research Carborane Nanoparticles
Zdroj:	ACS applied materialsinterfaces. 13(46)
ISSN:	1944-8252
Popis:	Boron neutron capture therapy (BNCT) is an encouraging therapeutic modality for cancer treatment. Prostate-specific membrane antigen (PSMA) is a cell membrane protein that is abundantly overexpressed in prostate cancer and can be targeted with radioligand therapies to stimulate clinical responses in patients. In principle, a spatially targeted neutron beam together with specifically targeted PSMA ligands could enable prostate cancer-targeted BNCT. Thus, we developed and tested PSMA-targeted poly(lactide
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5f8d13cd333c210027fa663fe116fb https://pubmed.ncbi.nlm.nih.gov/34752058 Zobrazit plný text záznamu