Impairment in long-term retention but not short-term performance on a water maze reversal task following hippocampal or mediodorsal striatal N-methyl-D-aspartate receptor blockade
| Autor: | Robert U. Muller, Matthew R. Holahan, Meira Louis, Franco A Taverna, John C. Roder, Robert J. McDonald, Stephen M. Emrich |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Hippocampus Water maze Striatum Hippocampal formation Receptors N-Methyl-D-Aspartate Piperazines Behavioral Neuroscience Internal medicine Basal ganglia medicine Reaction Time Animals Rats Long-Evans Maze Learning Analysis of Variance Memory Disorders Behavior Animal Chemistry Rats Endocrinology medicine.anatomical_structure Memory Short-Term nervous system NMDA receptor Memory consolidation Septal Nuclei Neuroscience Basolateral amygdala |
| Zdroj: | Behavioral neuroscience. 119(6) |
| ISSN: | 0735-7044 |
| Popis: | Male Long-Evans rats were injected with 32 ng/mul of the N-methyl-D-aspartate (NMDA) receptor antagonist 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) or vehicle and trained to locate a hidden platform in a different location (reversal training) than used on the initial 4 days of training. Rats treated with vehicle or CPP into the dorsal hippocampus, basolateral amygdala, or mediodorsal striatum had similar latencies to locate the platform on the reversal day. Rats infused with CPP into the dorsal hippocampus or mediodorsal striatum failed to search preferentially in the novel location during a 24-hr, drug-free retention test, whereas all other groups searched preferentially in this location. Therefore, blocking dorsal hippocampal or mediodorsal striatal NMDA receptors selectively blocked long-term spatial retention without producing short-term performance deficits. |
| Databáze: | OpenAIRE |
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