LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
| Autor: | Anthony G. Phillips, Donovan M. Ashby, Yu Tian Wang, Jeremy K. Seamans, Stan B. Floresco, Alexander McGirr |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Dorsal hippocampus Science Place cell Action Potentials General Physics and Astronomy Biology Hippocampal formation Hippocampus Article General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley 03 medical and health sciences Spatial memory 0302 clinical medicine Avoidance learning Avoidance Learning Animals Receptors AMPA CA1 Region Hippocampal Hippocampal synaptic plasticity Long-term depression Multidisciplinary Long-Term Synaptic Depression Excitatory Postsynaptic Potentials Long-term potentiation General Chemistry Endocytosis Sprague dawley Electrophysiology 030104 developmental biology Exploratory Behavior Peptides Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-20317-7 |
| Popis: | Hippocampal synaptic plasticity includes both long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength, and has been implicated in shaping place field representations that form upon initial exposure to a novel environment. However, direct evidence causally linking either LTP or LTD to place fields remains limited. Here, we show that hippocampal LTD regulates the acute formation and maintenance of place fields using electrophysiology and blocking specifically LTD in freely-moving rats. We also show that exploration of a novel environment produces a widespread and pathway specific de novo synaptic depression in the dorsal hippocampus. Furthermore, disruption of this pathway-specific synaptic depression alters both the dynamics of place field formation and the stability of the newly formed place fields, affecting spatial memory in rats. These results suggest that activity-dependent synaptic depression is required for the acquisition and maintenance of novel spatial information. LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats. |
| Databáze: | OpenAIRE |
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