The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency
| Autor: | Dorota Darmochwal-Kolarz, Monika Przegalinska-Kalamucka, Magdalena Michalak, Jan Oleszczuk, Agnieszka Bojarska-Junak, Dariusz Sliwa, Bogdan Kolarz |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Article Subject lcsh:Medicine Placental insufficiency Interleukin-23 General Biochemistry Genetics and Molecular Biology Preeclampsia 03 medical and health sciences Pregnancy Transforming Growth Factor beta Internal medicine Placenta medicine Humans General Immunology and Microbiology biology business.industry Interleukin-17 lcsh:R General Medicine Transforming growth factor beta Placental Insufficiency medicine.disease 030104 developmental biology Blood pressure Endocrinology medicine.anatomical_structure biology.protein Female Interleukin 17 business Research Article Transforming growth factor |
| Zdroj: | BioMed Research International, Vol 2017 (2017) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2017/6904325 |
| Popis: | Aim. The aim of the study was to evaluate the role of Interleukin-17 (IL-17), Interleukin-23 (IL-23), and transforming growth factor-β (TGF-β) in pregnancy complicated by placental insufficiency and in normal pregnancy. Material and Methods. The study comprised 34 patients with pregnancy complicated by fetal growth restriction (FGR) associated with preeclampsia (PE), as well as 35 healthy pregnant women. The concentrations of IL-17, IL-23, and TGF-β in sera from maternal peripheral blood were determined by an immunoenzymatic assay. Results. There were higher concentrations of IL-17 in the study group when compared to the controls. In the group of patients with placental insufficiency, the levels of IL-17 positively correlated with systolic blood pressure (R=0.42, p<0.01). The study obtained comparable concentrations of IL-23 in both studied groups. The concentrations of TGF-β were significantly lower in pregnancy complicated by the insufficiency of placenta when compared to the controls. Conclusions. It seems possible that the increased concentrations of IL-17 and the deficiency of TGF-β in pregnancy complicated by FGR and PE can be responsible for the activation of inflammatory response observed in PE cases. |
| Databáze: | OpenAIRE |
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