Introduction to Neurogenetics
| Autor: | William Renthal, Angeliki Vgontzas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Genetic Concepts
business.industry Genetic Variation Neurogenetics General Medicine Computational biology 030204 cardiovascular system & hematology Translational Research Biomedical Clinical Practice 03 medical and health sciences 0302 clinical medicine Genetic variation Humans Treatment strategy Medicine Genetic Predisposition to Disease 030212 general & internal medicine Nervous System Diseases business |
| Zdroj: | The American Journal of Medicine. 132:142-152 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/j.amjmed.2018.07.041 |
| Popis: | Genetic variation can directly cause or increase susceptibility to neurologic diseases. An explosion of new genetic technologies has enabled the characterization of specific genes responsible for many neurologic diseases and has provided fundamentally new insight into their pathophysiology. These advancements, along with recent breakthroughs in gene therapy, are beginning to result in the translation of an individual's genetic sequence into targeted treatment strategies. This review aims to introduce key genetic concepts and to illustrate how these principles apply in cases of rare, single-gene neurologic diseases as well as more common, polygenic diseases that are encountered frequently in clinical practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|