Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer
| Autor: | Waqar Ahmed, Iftikhar Ahmed Khan, Sakib Yousaf, Abdelbary Elhissi, Mohammad Najlah |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Liposome
Chromatography Materials science B230 Pharmaceutical Science Jet-nebulizer 02 engineering and technology Beclometasone dipropionate 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy 03 medical and health sciences Nebulizer 0302 clinical medicine Drug delivery Two-stage impinger medicine Proliposome 0210 nano-technology Pharmacology Toxicology and Pharmaceutics (miscellaneous) Aerosolization Tablets medicine.drug |
| ISSN: | 2093-5552 2093-6214 |
| Popis: | Purpose The aim of this study was to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer. Methods Proliposome powders were prepared by the slurry method and sorbitol or mannitol carbohydrate carrier were used in a 1:10 and 1:15 w/w lipid phase to carrier ratio. Beclometasone dipropionate (BDP; 2 mol%) was incorporated in the lipid phase. Proliposome powders were compressed into tablets, and liposomes were generated from proliposome powders or tablets within the nebulizer reservoir for subsequent aerosolization. Results Comparatively, shorter sputtering times were reported for the tablet formulations (≈ Conclusion Overall, this study showed that proliposome tablets could be disintegrated within a Pari-LC Sprint nebulizer to generate inhalable aerosol, with high drug output and hence can be manufactured on large scale to overcome the storage problems associated with powder formulations. |
| Databáze: | OpenAIRE |
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