AG-013736, a multi-target tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a Phase 2 study of cytokine-refractory, metastatic renal cell cancer (RCC)
| Autor: | Gary R. Hudes, S. D. Reich, Oliver Bolte, Robert J. Motzer, Olivier Rixe, Ronald M. Bukowski, M.D. Michaelson, Brian I. Rini, G. Wilding, Heidi Steinfeldt |
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| Předmět: |
Antitumor activity
Cancer Research endocrine system diseases Tumor suppressor gene biology business.industry medicine.medical_treatment Phases of clinical research urologic and male genital diseases female genital diseases and pregnancy complications Receptor tyrosine kinase Cytokine Multi target Oncology Refractory Immunology Cancer research medicine biology.protein cardiovascular diseases business neoplasms Gene |
| Zdroj: | Memorial Sloan Kettering Cancer Center |
| Popis: | 4509 Background: Clear cell renal carcinoma (RCC) is characterized by inactivation of the von Hippel-Lindau tumor suppressor gene, which leads to overexpression of hypoxia-regulated genes including... |
| Databáze: | OpenAIRE |
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