GENDER DIFFERENCES IN THE EFFECT OF DIABETES MELLITUS AND ITS TREATMENT ON OSTEOARTHRITIC PAIN
| Autor: | Monica Vannucci Nunes Lipay, Marcelo de Azevedo e Souza Munhoz, Martha Cecilia Castano Betancourt, Evaldo Marchi, Jordane Aragão, Caroline Larissa Morais, Eduardo Gomes Machado |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty rheumatologic/musculoskeletal disease Knee Joint Endocrinology Diabetes and Metabolism Population Analgesic Osteoarthritis Severity of Illness Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Sex Factors Risk Factors Internal medicine Diabetes mellitus Humans Hypoglycemic Agents Medicine pain Epidemiology/Health Services Research education Aged Pain Measurement 030203 arthritis & rheumatology Sex Characteristics education.field_of_study business.industry Middle Aged Osteoarthritis Knee Anthropometry medicine.disease Arthralgia Diabetes Mellitus Type 2 Joint pain Female Hip Joint adult diabetes medicine.symptom business Body mass index 030217 neurology & neurosurgery Cohort study |
| Zdroj: | BMJ Open Diabetes Research & Care |
| DOI: | 10.5151/sbr2019-459 |
| Popis: | Objective(1) To investigate differences in pain severity and its distribution between patients with and without diabetes mellitus (DM) in a population with advanced osteoarthritis (OA). (2) To explore the role of medication used for diabetes in these associations.Research design and methodsThis is a hospital-based cohort study of patients with advanced OA requiring total joint arthroplasty. Interviews and electronic records included: age, gender, occupation, DM (including medication and duration), analgesics used, anthropometry, joints affected by pain and disease duration. Joint pain was scored by the patients using numerical rating scale. Pain severity score was calculated by adding the number of joints affected by pain and the maximum pain score. All analyses were adjusted and/or stratified by gender, age and body mass index.ResultsIn total, 489 patients with painful OA were included. From those, 139 patients had DM (30% males and 28% females, p=0.03). Pain severity, principally the number of joints affected by pain, and analgesic consumption, was higher in males with diabetes compared with males without diabetes (p=0.012 and OR=3.03; 95% CI 1.24 to 7.36, p=0.015, respectively). These associations were not significant in females (p=0.41 and p=0.66). Pain was more severe in males using insulin versus those who did not (p=0.025). Male subjects with diabetes had higher odds of hand pain or knee and hand pain compared with males without diabetes (OR=3.7, 95% CI 1.15 to 12; p=0.028 and OR=5.54; 95% CI 1.43 to 21.5, p=0.013, respectively).ConclusionsMales with diabetes, especially those who require insulin, have more severe joint pain and consume more analgesics than males without diabetes or those who have DM and use other DM medication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|