Protective effect of ghrelin on testicular damages caused by chronic hypoxia in rats: A histopathological study
| Autor: | Alireza Alihemmati, A. Hazrati, Ramin Salimnejad, F. Mirzaei Bavil, Mohammad Reza Alipour |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Germinal epithelium medicine.medical_specialty 030219 obstetrics & reproductive medicine business.industry Urology digestive oral and skin physiology General Medicine Oxygenation Hypoxia (medical) medicine.disease_cause 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Apoptosis Internal medicine medicine Room air distribution Ghrelin medicine.symptom business Spermatogenesis Oxidative stress |
| Zdroj: | Andrologia. |
| ISSN: | 1439-0272 |
| Popis: | Hypoxia can lead to changes in the blood flow, nutrition and oxygenation of male germ cells and results in fertility reduction through the increase in oxidative stress. This study aims to evaluate the effect of ghrelin on testicular damage induced by hypoxia in rats. In this experimental study, 24 male rats were randomly divided into four groups: control, hypoxia, hypoxia + ghrelin and ghrelin. Animals in the control and ghrelin groups were kept in room air with 21% oxygen. The animals in the groups of hypoxia and hypoxia + ghrelin were subjected to 11% oxygen for 14 consecutive days in the hypoxia chamber. At the end of the study, the testes were removed and histological changes, as well as the apoptotic index, were investigated. Morphometrical analysis showed that hypoxia caused a significant decrease in the seminiferous tubules diameter, the germinal epithelium thickness and main Johnson's score compared to the control group (p |
| Databáze: | OpenAIRE |
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