Dual-Time-Point 18F-Fluorocholine PET/CT Improves Characterization of Thyroid Nodules in Patients Referred for Primary Hyperparathyroidism
| Autor: | David Morland, Mihaela Ignat, Jacob Bani, F. Hubelé, Adrien Latge, Khalil Bourahla, Mohamad Zalzali, Michel Vix, Alessio Imperiale, David Taïeb |
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| Přispěvatelé: | Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Laboratoire de Biophysique, UFR de médecine, Université de Reims Champagne Ardenne, Reims, France |
| Rok vydání: | 2021 |
| Předmět: |
Thyroid nodules
medicine.medical_specialty endocrine system diseases [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging Population medicine.disease_cause 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Medicine Radiology Nuclear Medicine and imaging education Thyroid cancer ComputingMilieux_MISCELLANEOUS Thyroid neoplasm education.field_of_study PET-CT business.industry Thyroid Nodule (medicine) General Medicine medicine.disease 3. Good health medicine.anatomical_structure 030220 oncology & carcinogenesis Radiology medicine.symptom business Primary hyperparathyroidism |
| Zdroj: | Clinical Nuclear Medicine Clinical Nuclear Medicine, Lippincott, Williams & Wilkins, 2021, 46 (12), pp.965-970. ⟨10.1097/RLU.0000000000003904⟩ |
| ISSN: | 1536-0229 0363-9762 |
| Popis: | Purpose Thyroid nodules frequently coexist with primary hyperparathyroidism (pHPT). Because of the increasing use of 18F-fluorocholine (18F-FCH) PET/CT in patients with pHPT, evaluation of its clinical utility for thyroid nodules characterization in this population is of paramount importance. Herein, we investigate the value of dual-point 18F-FCH PET/CT in the diagnosis of thyroid cancer in patients referred for pHPT imaging who have thyroid nodules. Patients and methods All pHPT patients who underwent a dual-time point 18F-FCH PET/CT (at 5 and 60 minutes postinjection) between July 2019 and December 2020 were analyzed. Only those with a thyroid nodule greater than 10-mm and pathological analysis (criterion standard) were included. Nodule-to-thyroid SUVmax ratio was calculated at the 2 study points, as well as the 18F-FCH washout index (WO%). Results Twenty-seven patients (32 nodules) were included in this study. The final diagnoses were as follows: 27 benign nodules including 2 NIFTPs (noninvasive follicular thyroid neoplasm with papillary-like nuclear features) and 5 cancers of follicular origin. Early uptake ratio was significantly higher in malignant lesions than in benign nodules (P = 0.0008). Thyroid cancers were also characterized by a marked 18F-FCH washout index (WO% benign vs cancer: 2.9% ± 4.1% vs 45.5% ± 13.4%, P = 0.0001). Using a WO% threshold of 22.1%, 25/27 benign nodules and 5/5 malignant lesions were accurately classified (sensitivity of 100%, specificity of 92.6%, positive predictive value of 71.4%, and negative predictive value of 100%). The false-positive findings were related to the 2 NIFTPs that share similarities with thyroid cancer. Conclusions Our preliminary results suggest to perform a dual-time-point PET/CT acquisition protocol in pHPT patients with uncharacterized centimeter thyroid nodules. However, the real impact of these promising results should be assessed by prospective studies on a larger cohort of patients. |
| Databáze: | OpenAIRE |
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